Reference #: 1009561 SHIFT:Day (United States of America)

A Brief Overview Assume responsibility for an on-going, innovative research project as a Postdoctoral Fellow at CHOP. Our postdoc experience will broaden your skillset, scientific background, and research capabilities.

CHOP's Commitment to Diversity, Equity, and Inclusion CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

Responsibilities * Participate in project planning, recording, and evaluation of data. * Conduct independent scholarly research, developing new methods and protocols under the guidance of a mentor (principal investigator). * Acquire technical, lab management, and grant writing skills. * Participate in seminars, lectures, poster sessions, national presentations, and professional workshops. * Supervise junior lab members. * Assist with other research projects as needed. Education Qualifications Doctorate (required)

About the Lab:

One NIH-sponsored postdoctoral fellow position is available in Dr. Nik Sgourakis 's lab at theCenter for Computational and Genomic Medicine and the Department of Biochemistry and Biophysics at the Children's Hospital of Philadelphia (CHOP), and the Perelman School of Medicine at the University of Pennsylvania (UPenn).

The major focus of the laboratory is to investigate the molecular mechanisms of MHC-I antigen processing and presentation, including non-classical MHC molecules, toward novel synthetic biology applications and clinical translation through the development of targeted therapeutics. For more information, visit:

Multiple protein design-based projects are available: (1) Design of novel immunological chaperones; (2) Structure-guided design of synthetic immune receptors.

Recent relevant publications: 1. Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion. Science Immunology, 2023 2. TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap. Nature Communications, 2021 3. Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection. PNAS, 2019

Applications should have experience with yeast display methods for protein engineering. Students who just received or are expected to receive their degree are encouraged to apply.

The position is available for immediate hire. Applicants should send a Cover letter, CV including research interests, bibliography, and contact information for three references to Nik Sgourakis: nikolaos.sgourakis@pennmedicine.upenn.edu

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must be fully vaccinated against COVID-19 and receive an annual influenza vaccine.

Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed.

|

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.